iranian journal of basic medical sciences

22, No. FIFTY PREGNANT WISTAR RATS WERE RANDOMLY DIVIDED INTO FIVE GROUPS: 1- nano-silver (N.S) group; 30 mg/kg of N.S treated via gavage. Despite extensive research in understanding the mechanism of Th17 and Treg differentiation, the role of microRNAs in MS is not completely understood. Journal Abbreviation: IRAN J BASIC MED SCI. It has been notified that ion channels' activities in cardiomyocytes are sensitive to the ATP level. Objective(s): To investigate the role of the microRNA-125a (miR-125a) and BAK1 in intervertebral disc degeneration (IDD). RORC and FOXP3 were up-regulated in relapsing and remitting phases of MS, respectively. Image analysis software was used to determine the expressions of CD11a, CD11b, and CD11c integrins quantitatively. Plasma free fatty acids profile was studied by gas chromatography. Materials and Methods: Iranian Journal of Basic Medical Sciences CircRNA_0109291 regulates cell growth and migration in oral squamous cell carcinoma and its clinical significance 6, Jun 2013 773 symptoms such as parenthesis, ataxia, dementia, depression and psychosis (2). However, apart from thiamin pyrophosphate, none of the drugs were able to prevent infertility caused by I/R injury. Immunohistochemistry was performed to determine expression Fas, FasL, and MMP-3. Data provided are for informational purposes only. miRNA-125a may regulate the apoptosis status of the NPCs by inhibiting the expression of its target gene BAK1, which provided a potential strategy for further development of IDD therapies. Results: Circulating endothelial cells (CECs) and EPCs were assayed using flow cytometry. The bacteria including pET32a-hylA (hylA is abbreviation of Streptococcus pyogenes hyaluronidase gene and hylA is abbreviation of Streptococcus pyogenes hyaluronidase protein) plasmids were induced by IPTG and analyzed by SDS-PAGE. ConclusionWe conclude that oxypeucedanin (found in some vegetables) can be considered as an antiproliferative agent. Iranian Journal of Science and Technology, Transaction A, Science (ISTT) is devoted to significant original research articles of moderate length (not more than 15 pages in the ISTT format), in a broad spectrum of Biology, Chemistry, Geology, Mathematics, and Physics.Special attention will be paid to applications of these fields in medical science and multidisciplinary research. Glaucoma is the second leading cause of blindness and it is related to oxidative stress based on numerous studies. For this study, 108 non-duplicate A. baumannii isolates were obtained from clinical specimens in four teaching hospitals in Qom in the central of Iran. The Iranian Journal of Basic Medical Sciences (IJBMS) is a peer-reviewed, monthly publication by Mashhad University of Medical Sciences (MUMS), Mashhad, Iran. The burst was significantly lower with composite microparticles and may be explained by lower diffusion of the drug from double polymeric wall formed by the nanoparticles matrix followed by another diffusion step through the microparticle polymeric wall. The aim of this study was to determine the seroprevalence of anti-Helicobacter pylori and anti-cytotoxin-associated gene A (CagA) antibodies in asymptomatic healthy population in the center of Iran and to investigate the relation with different parameters. No effect was observed with the dextran-induced oedema model. ISO 4 (Information and documentation – Rules for the abbreviation of title words and titles of publications) is an international standard, defining a uniform system for the abbreviation of serial publication titles. An up-regulation of miR-9-5p and down-regulation of miR-106a-5p in relapsing phase of MS patients were observed compared to healthy controls. Mild hypothermia (33±0.5°C) for 6 hr was initiated at the start of reperfusion. Materials and Methods: Quasi-emulsion solvent diffusion was used as a crystal modification method. The Journal welcomes original clinical articles as well as basic science research experiences mainly on prevalent diseases in the region and the analysis of various regional problems. This study demonstrates the beneficial effects of Zataria multiflora extract on insulin resistance in rats fed with a high-fructose diet through at least three mechanisms including direct insulin like effect, increasing in adiponectin and of PPARγ protein expression. In the current study formulations were characterized by loading efficiency, yield, particle size, zeta potential, X-ray diffraction (XRD) and differential scanning calorimetry (DSC).ResultsIn microparticles, the best drug to polymer ratio was 0.8:1 (F3). Cerebrum of six offsprings in each group was removed and stained with cresyl violet and a monoclonal antibody NeuN for immunohistochemical detection of surviving pyramidal neurons. The enzymatic evaluation and antigenicity was finally studied. Thirty male Sprague–Dawley rats were divided into three groups: control, untreated diabetic and diabetic rats treated with GSP. Conclusion: Iranian Journal of Basic Medical Sciences. Cell proliferation-associated proteins and cell apoptosis-associated proteins were analyzed by Western blot. Objective (s) Porin is a mitochondrial outer membrane channel, which usually functions as the pathway for the movement of various substances in and out of the mitochondria and is considered to be a component of the permeability transition (PT) pore complex that plays a role in the PT. All 5 groups received methanolic extract of S. atropurpurea (MESA) at a dosage of 50; 100; and 200 mg/KgBW. Recent evidence indicates that Interleukin 17 (IL-17)-producing T helper cells (Th17 cells) population are increased and regulatory T cells (Treg cells) are decreased in MS. Finally, the brains of rat offspring were removed to use for nano-silver level measurement and TUNEL staining. Hypoxia-induced increase in levels of serum cGMP and TNF-α was reversed by thoracic epidural blockade. This study also provided morphological data to investigate the signal transduction mechanisms of myocardial hypertrophy and reverse it. Mice were orally administered with B. monnieri at the doses of 40, 80 or 120 mg/kg body weight along with PBDE-209 (20 mg/kg body weight) from postnatal day (PND) 3-10. Results Our results showed that the LEPR Q223R polymorphism is associated with increased breast cancer risk as well as tumor grade in a sample of Iranian subjects. The correct choices and reference/working memory errors of young mice were evaluated by Morris water and radial arm maze. In this study, in search for a splice model system to facilitate the evaluation of AOs to redirect defective splicing of IVSI-110 β-globin intron, an EGFP-based IVSI-110 specific cellular reporter assay system has been developed and a number of AOs were tested in this cellular splicing assay. Rat models had received the middle cerebral artery occlusion (MCAO) or sham operation before grouping, and cell models of oxygen-glucose deprivation (OGD) were performed. Flow cytometry was determined the NPCs apoptosis, and Western blot to measure the expressions of BAK1, Caspase-3, Bax and Bcl-2. There was statistically inverse association between H. pylori infection and education level (P=0.04) and marital status (P=0.000). nicotinamide/streptozotocin-induced diabetic rats were supplemented orally with three different doses of D. aucheri (100, 200 and 400 mg/kg BW) or glibenclamide (0.25 mg/kg) for 4 weeks. Considering the fact that in the prostate adenocarcinoma there is no basal cell layer, basal cell markers can help to differentiate prostate adenocarcinoma from cancer mimickers. BM plays a neuroprotective role against PBDE-209-induced alterations in oxidative status. However, it would be more satisfactory to obtain directly during the crystallization step crystalline particles that can be directly compressed and quickly dissolved. Additionally, BAK1 is the target gene of miRNA-125a. Male Wistar rats were randomly divided into normal-control, diabetic-control, and A. marmelos-treated diabetic groups (100, 250 and 500 mg/kg, p.o.). The present study investigated the antidiabetic and hypolipidemic properties of Dorema aucheri leave hydroalcoholic extract in nicotinamide-streptozotocin induced type 2 diabetic rats. The obtained agglomerates exhibited significantly improved micromeritic properties as well as tableting behavior than untreated drug crystals. For this purpose, we used in vivo 4-vessel occlusion model of rat brain and porin purification method by hydroxyapatite column. Objective(s) Materials and Methods 3- N.S and garlic (N.S+G) group; N.S (30 mg/kg) and garlic juice (1 ml/100 g) treated via gavage simultaneously. Results: from Rutaceae family is widely used in Iranian folk medicine for the treatment of diabetes mellitus. Objective(s)Diabetes mellitus is associated with disturbances of learning and memory and cognitive functioning. The control animals received an equivalent volume of normal saline. This study suggests that thiamine pyrophosphate may be useful in the prevention of I/R-related infertility in diabetics. Objective(s): Using reference management software Typically you don't format your citations and bibliography by hand. Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) was utilized to assess the expression of miRNAs and mRNAs, in 40 RR-MS patients and 11 healthy individuals. The relaxant effects of three cumulative concentrations of each fraction (0.1, 0.2 and 0.4 g%) in comparison with saline and three cumulative concentrations of theophylline (0.1, 0.2, and 0.4 mM) were examined on precontracted tracheal chains of guinea pig by 60 mM KCl (group 1, n= 5) and 10 µM methacholine (group 2, n= 8). In the present research, we standardized some techniques to isolate GBCs from rat olfactory epithelium in pure form using a highly selective GBC-III antibody passaged through fluorescence activated cell sorter (FACS). Results: Materials and Methods Materials and Methods Differentiation of prostate adenocarcinoma from benign prostate lesions and hyperplasia sometimes cannot be done on the basis of morphologic findings. All the interventions were done during pregnancy (21 days). Prevention of ovarian I/R injury-related infertility in rats with induced diabetes is not through antioxidant activity. Serum cyclic GMP (cGMP) and TNF-α were measured using radioimmuno assay. Basic and Clinical Neuroscience (BCN) is an open-access journal, which is the official publication of Iran University of Medical Sciences and the Iranian Neuroscience Society. When categorizing the asthmatic patients in severe, moderate and mild groups, associations in the subcategories of asthmatic patients were found. Dual-luciferase assay was used for analyzing the targeting relationship between miR-103 and VEGF. The eluted product was cloned into the prokaryotic expression vector pET32a which was digested by BamHI and HindIII restriction endonuclease enzymes. No antipathogenic and antioxidant activity were found for oxypeucedanin in this study. Results Thereby, as a step closer, we analyzed the expression profile of miR-9-5p and miR-106a-5p, and protein level of retinoic acid receptor (RAR)-related orphan receptor C (RORC; Th17 master transcription factor) as direct target of miR-106a-5p and forkhead box P3 (FOXP3; Treg master transcription factor) as indirect target of miR-9-5p in CD4⁺ T cells in two groups of relapsing and remitting in our relapsing-remitting MS (RR-MS) patients. With optimized wet agglomeration temperature, spherical, dense, and strong agglomerates can be obtained. To investigate the effects of local mild hypothermia on the expression of Fas, FasL and MMP-3 after cerebral ischemia-reperfusion in rats. Results: Significantly more FN, Smad3 and IGFBPrP1 were expressed in treatment groups than those in normal group. Materials and Methods: The aim of study was to formulate and evaluate effect of the microencapsulation of theophylline loaded nanoparticles on the reduction of burst release.Materials and Methods Finally, the 1:1 mixture of naproxen and each excipient was tabletted, and hardness and friability of different tablets were evaluated. NADPH oxidase activity, measured by lucigenin-enhanced chemiluminescence and of NOX1 and NOX2 protein levels were increased in aortic homogenates from SHR compared to WKY. Iranian Journal of Basic Medical Sciences Experimental therapeutic studies of Solanum aculeastrum Dunal. Evaluation of the agglomerates along the course of agglomeration shows that the properties of the particles change gradually but substantially. This study dealt with the wet agglomeration process in which a small quantity of binder liquid was added into a suspension of crystals, directly in the stirring vessel where the crystallization took place. The seroprevalence of anti-H. pylori IgG was higher in males (74.6%) than in females (71.6%). The XRPD and DSC results showed that during the agglomeration process, ibuprofen did not undergo any polymorphic changes.Conclusion The study highlights the influence of surfactants on crystallization process leading to modified performance. QRT-PCR was used to detect the expression of miR-125a and BAK1, and apoptosis of NP tissues detected by TUNEL staining. A Statistically significant correlation (r = 0.737) between QTc (ms) and the age of LQTS patients has been reported. MiR-125a was reduced while BAK1 was elevated in IDD patients with the increase of Pfirrmann grade. Objectives: Additionally, there were significant association between Q223R genotypes and breast cancer risk; homozygotes for RR genotype (OR= 6.840; 95% confidence interval [CI] = 2.434-19.218), heterozygotes for QR (OR=3.024; 95% CI = 1.620-5.644, P = 0.001), and QR+RR genotype (OR= 3.522; 95% CI = 1.934-6.414, P < 0.001), respectively. Here we investigated the expressional regulation of NADPH oxidase isoforms (NOX1, NOX2 and NOX4) in aorta of aged spontaneously hypertensive rats (SHR) in comparison to age matched Wistar Kyoto rats (WKY). Results: Apoptosis was examined by TUNEL assay. Diabetes plays an important role in the induction of the liver injury. In nanoparticles, F4 formulation (0.4:1 drug/polymer ratio) showed high production yield (40.8%), loading efficiency (99.05%), low particle size (756 nm) and minimum burst effect compared with other nanoparticle formulations. Materials and Methods: Conclusion: The seroprevalence of anti-CagA IgG was in males 48.6% and in females 31.6%. Overall, the diversity of RFLP among 95 tuberculosis patients were 48, 50 and 45 on the basis of IS6110, PGRS and DR patterns, respectively. Totally, 525 individuals aged 17-60 years were enrolled in study. miR-122 overexpression decreased cell viability and migration, and increased cell apoptosis in hypoxia- treated PC-12 cells, but miR-122 silencing led to the opposite results. GSP have protective effects against hepatic tissue injury due to antioxidant properties. PC-12 cells were cultured under anoxic condition for induction of hypoxia injury and/or treatment with Quer, transfection with pre-miR-122, anti-miR-122 or their negative controls. Objective(s)In the present study, the differences in the relaxant effects of aqueous, ethyl acetate and n-butanol fractions of Rosa damascena on tracheal smooth muscle of guinea pigs were examined. Solvent systems consist of ethyl acetate and dichloromethane for microspheres and nanospheres, respectively. Inhibition of miR-103 could promote ischemic stroke angiogenesis and reduce infarction volume via enhancing VEGF, which provides a new target for the clinical treatment of ischemic stroke. Iranian Journal of Basic Medical Sciences Mesenchymal stem cells that located in the electromagnetic fields improves rat model of Parkinson's disease Majid Jadidi 1, Saeed Moghadas Biat 22, Hamid Reza Sameni , Manouchehr Safari *, Abbas Ali Vafaei 43, Laya Ghahari The aim of this study was to investigate the effects of nano-silver and garlic administration during pregnancy on neuron apoptosis in rat offspring hippocampus. There was no statistically significant association between anti-CagA IgG positivity and age, occupation, socioeconomic status, ABO blood groups and Rh status. Objective(s) Iranian Journal of Basic Medical Sciences' journal/conference profile on Publons, with 287 reviews by 71 reviewers - working with reviewers, publishers, institutions, and funding agencies to turn peer review into a measurable research output. The expressions and distributions of CD11a, CD11b, and CD11c integrins were detected by immunohistochemistry. Although carefully collected, accuracy cannot be guaranteed. In each group of animals, spatial learning and memory parameters were analyzed. The present study aimed at determining the antibiotic susceptibility profiles and the distribution of OXA-type beta-lactamases among Iranian Acinetobacter baumannii isolates from Qom of Iran. Degree of pulmonary vascular remodeling was determined by Hematoxylin and Eosin (HE) staining. This work also throws some light on ionic channels present on these stem cells which are responsible for their neuron induction potential. This study aimed to investigate the role of Quercetin (Quer) in hypoxia-induced injury of pheochromocytoma (PC-12) cells. The XRD and DSC showed stable character of theophylline in the drug loaded microspheres. Journal Abbreviation: IRAN J BASIC MED SCI Four novel mutations that lead to an amino acid substitution and two mutations in mitochondrial tRNA have been informed in this study. This is a case-control study, where four SNPs S1 (rs3918396), T1 (rs2280091), T2 (rs2280090), V4 (rs2787094) of ADAM33 gene have been assessed in patients with allergic asthma and normal controls (95 patients and 86 normal). Finally, main components in AMP-activated protein kinase (AMPK) and Wnt/β-catenin signaling pathways were analyzed by Western blot. Melatonin, famotidine, mirtazapine, and thiamin pyrophosphate prevented a rise in oxidant parameters and a decrease in antioxidants in ovarian tissue exposed to I/R. Male Wistar rats were divided into sham-operated group (Sham), normothermia group (NT), and hypothermia group (HT). This effect could be attributed to hypoglycemic, hypolipidemic and antioxidant activity of A. marmelos. Besides, miRNA-125a was negatively correlated to the NPCs apoptosis, while BAK1 mRNA was positively correlated to cell apoptosis. Basal cell markers can help to distinguish prostate adenocarcinoma from cancer mimickers. The Iranian Journal of Basic Medical Sciences (IJBMS) is a peer-reviewed, open access, monthly publication by Mashhad University of Medical Sciences (MUMS), Mashhad, Iran . To clarify the protective effects of Cichorium glandulosum (CG) extracts on thioacetamide (TAA)-induced rat hepatic fibrosis. Grape seed proanthocyanidin (GSP) have a wide range of medicinal properties against oxidative stress. In this study we evaluated antioxidant effects of GSP on liver in streptozotocin-induced diabetic rats. Objective(s): Higher temperature of the system during agglomeration process favors the formation of more regular agglomerates with mechanically stronger and denser structure; this can be explained by the promotion effect of temperature on the agglomeration process. The objective of this study was to find a stable microemulsion vehicle for transdermal delivery of ibuprofen to improve the skin permeability. The research data show that these mitochondrial mutations, in a family with LQTS, might be the responsible mitochondrial that defect and increase the gravity of LQTS. Serum levels of leptin and soluble leptin receptor (sOB-R) were measured by ELISA method. 2018 Jan;21(1):1-2. doi: 10.22038/IJBMS.2017.28276.6862. 180: 2013 “Silymarin”, a promising pharmacological agent for treatment of diseases. ISSN; 20083874, 20083866. The dissolution tests showed that the agglomerates obtained in presence of SLS exhibited enhanced dissolution rate while the agglomerates made in the presence of Tween 80 had no significant impact on dissolution rate of ibuprofen in comparison to untreated sample. In mild hypothermia group, numbers of Fas-positive and MMP-3 positive cells were significantly less than those of normothermia group (P<0.05). Globose basal stem cells were isolated from rat olfactory epithelium using GBC-III antibody and were characterized as multipotent stem cells using various neural progenitor markers. Carbamazepine was used as a model drug and water/ethanol and isopropyl acetate were used as crystallization system and binder liquid, respectively. Degenerative lumbar nucleus pulposus (NP) tissues were obtained from 193 patients who underwent resection, and normal controls consisted of normal NP tissues from 32 patients with traumatic lumbar fracture in our hospital. Down-regulating miR-103 with the miR-103 inhibitor enhanced VEGF, ameliorated the neurological scores, decreased infarct volume, and increased vascular density in rats after MCAO. It was concluded that the increased frequencies of GSTM1 null in patients with PCAG could be a risk factor for incidence of PCAG in the Iranian population. The rats were divided in 5 groups: control (normotensive) group, Desoxy cortico sterone (DOCA)-salt hypertensive group, and three DOCA-salt hypertensive groups. Articles from Iranian Journal of Basic Medical Sciences are provided here courtesy of Mashhad University of Medical Sciences. In general, it is possible to produce the enzymatic regions of the Streptococcus pyogenes hyaluronidase in E. coli. Furthermore, the impaired acetylcholine-induced relaxation of SHR aorta was significantly improved in the presence of either apocynin or VAS2870. After peer-review by expert national and international reviewers, 15 % of submitted papers were accepted for publication. We have investigated the effect of Q223R polymorphism on the breast cancer susceptibly in a sample of Iranian subjects. We found the reduced miR-103 in rats after MCAO. In addition, siBAK1 can reverse the pro-apoptosis function of miR-125a inhibitors in NPCs. Enzymes digestion analysis, sequencing results showed that the target gene (1296 base pair) was inserted correctly into the recombinant vector. To examine the expressions of CD11a, CD11b, and CD11c integrins in the myocardial tissues of rats with isoproterenol-induced myocardial hypertrophy. Conclusion Changes in the mRNA expressions of CD11a, CD11b, and CD11c in the myocardial tissues of rats were detected by RT-PCR. This study investigated the effects of melatonin, famotidine, mirtazapine, and thiamine pyrophosphate on ischemia/reperfusion (I/R) injury in diabetic rats and evaluated oxidant and antioxidant marker measurement results. Administration of GSP significantly ameliorated structural changes induced in liver of diabetic rats. Objective(s)Theophylline, a xanthenes derivative, is still widely used as an effective bronchodilator in the management of asthmatic patients. The results showed a potent relaxant effect for ethyl acetate fraction of R. damascena on tracheal smooth muscle comparable to that of theophylline but a relatively weak relaxant effect for aqueous and n-butanol fractions at concentrations used. Aegle marmelos Corr. The Journal Impact 2019-2020 of Iranian Journal of Basic Medical Sciences is 1.960, which is just updated in 2020. To our knowledge, there are few reports on pharmacological and biological activities of this compound. There was no association between asthmatic patients and polymorphisms of alleles, genotypes and haplotypes of the ADAM33 gene. Ionic channels on GBCs were studied with voltage clamping. The antimicrobial susceptibility of isolates was tested by standard disk diffusion and prevalence of bla OXA genes was investigated by PCR method. Quantitative computer-assisted morphometric study was done on hippocampus. Results: 167: Selection of the appropriate target site is essential in the success of an AO therapy. Iranian journal of basic medical sciences 14 (4), 308, 2011. The mean droplet size of microemulsion was about 43 nm and no skin irritation signs were observed on the skin of rabbits. Conclusion: Compared with historical Journal Impact data, the Metric 2019 of Iranian Journal of Basic Medical Sciences grew by 12.64%. Thoracic epidural blockade reduced mPAP and serum level of TNF-α and increased cGMP. Flow parameters, particle size and thermal behavior of the treated powders were compared with the native starch. The dry roots of CG were smashed and percolated with 95% ethanol, and the residual was prepared into petroleum ether extract (CG-V), ethyl acetate extract (CG-VI) and n-butyl alcohol extract (CG-VII). IJBMS, in 2014, continued the rapid forward trend of the recent years, notably 2011 through 2013. Objective(s)Current study was undertaken to investigate the analgesic and anti-inflammatory effects of the aqueous extract of Teucrium chamaedrys in mice and rats. The purpose of this study was to compare the genetic patterns of Mycobacterium tuberculosis by three methods of RFLP technique. ResultsIn group 1, all concentrations of theophylline, ethyl acetate fraction and two final concentrations of n-butanol fraction showed significant relaxant effects in comparison with saline (p< 0.05 to P< 0.001). Meanwhile, si-VEGF could reverse the effect of miR-103 inhibitor on angiogenesis in rats subjected to MCAO. All patients were graded according to the Pfirrmann criteria. Results of the phytochemical screening show the presence of alkaloids, flavonoids and triterpenoids in the extract.Conclusion Conclusion: Serum nitric oxide (NO) was assayed by colorimetric. The extract also inhibited acetic acid-induced abdominal writhes in a dose-dependent manner. This study demonstrated high genetic diversity of OXA genes among isolates of A. baumannii in Qom, Iran. Objective(s): Objective(s): After Quer treatment, viability, migration, and cell apoptosis of PC-12 cells were analyzed by CCK-8 assay, transwell assay and flowcytometry analysis, respectively. Polymorphisms of ADAM33 gene might be associated with severe asthma and sensitivity to aeroallergens in northeast of Iran, but further studies are needed to determine the polymorphisms in this area and other regions of our country. The mRNA expressions of CD11a, CD11b, and CD11c in the myocardial tissues of rats were consistent with the immunohistochemical results. After isolation of non- degenerative and degenerative nucleus pulposus cells (NPCs), the targeting relationship between miR-125a and BAK1 was verified by dual luciferase reporter gene assay. Iranian Journal of Basic Medical Sciences . Ropivacaine-treated rats exhibited significantly lower mean pulmonary artery pressure (mPAP), ratio of right ventricular weight to left ventricular plus septal weight (RV/(LV+S)) and wall thickness of pulmonary artery compared with those of control rats. Considering the beneficial antidiabetic potential of A. marmelos, this study was conducted to evaluate the effect of chronic oral administration of A. marmelos as cognitive enhancer, on learning and spatial memory in diabetic rats using Morris water maze test. The agglomeration of crystals was carried out at various temperatures and the agglomerates were characterized in terms of size, morphology, density and mechanical strength. The Journal of "IJBMS” is a modern forum for scientific communication. In the control group exposed to I/R, the levels of the oxidant parameters Malondialdehyde (MDA) and Myeloperoxidase (MPO) were significantly higher compared with the SO group, while the levels of the antioxidant parameters glutathione (GSH), Glutathione peroxidase (GPO), Glutathione reductase (GSHRd), Glutathione S - transferase (GST), and Superoxide dismutase (SOD) were significantly lower. A number of AOs with a 2'-O-methyl oligoribonucleotide (2'-O-Me) backbone system were systematically tested in this cellular splicing assay. Iranian Journal of Basic Medical Sciences Vols. ResultsClear impairment of spatial learning and memory was observed in diabetic group versus normal-control group. Data also indicated that enzymatic region of hyaluronidase protein from Streptococcus pyogenes was recognized in all 5 patient's sera. MESA100 and MESA200 also elevated the EPCs number compared with hypertensive group. Conclusion: Materials and Methods Materials and Methods: The Standard Abbreviation (ISO4) of Iranian Journal of Basic Medical Sciences is “Iran J Basic Med Sci”. The agglomerates size and size distribution was largely controlled by surfactant concentration, but there was no significant influence found on the tableting properties. Multiple sclerosis (MS) is considered as a chronic type of an inflammatory disease characterized by loss of myelin of CNS. The optimum formulation F3 consisting of 6% oleic acid, 30% Cremophor RH40/Transcutol P (2:1, w/w) and 59% water phase, showed a high permeation rate of 42.98 µg/cm(2)/hr. Almost half of the infected individuals acquire CagA-positive strains of H. pylori. For a complete guide how to prepare your manuscript refer to the journal's instructions to authors. The mutation in the intron causes aberrant splicing of EGFP pre-mRNA, preventing translation of EGFP; however, treatment of the cells with specific concentration of a sequence specific 2'-O-Me AO targeted to the aberrant splice site induced correct splicing and resulted in restoring of EGFP activity. Streptococcus pyogenes produces extracellular hyaluronidase enzyme. In a cross-sectional and prospective study, 95 strains of M. tuberculosis isolates were selected for DNA fingerprinting. 2- Control (C) group, administrated with distilled water via gavage. Improving function of nerve cells is important for treating cerebral anoxia. Twenty of these patterns (21.1%) with IS6110-RFLP, twenty-two (23.2%) with PGRS-RFLP and seventeen (17.9%) with DR-RFLP occurred with unique RFLP patterns, whereas the remaining 28 patterns were communal. CC BY-NC 4.0 by Journal of Basic Research in Medical Sciences (JBRMS) is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

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